The UCSD Center for Liquid Biopsy is created to transform liquid biopsy-based disease diagnosis and personalized treatment. We develop and validate disease biomarkers based on circulating cell-free RNA, extracellular DNA, proteins, metabolites, and extracellular vesicles. We develop technologies for sensitive detection and accurate quantification of candidate biomarkers from body fluids. We combine these technologies with single-cell analysis of PBMC and circulating tumor cells and validate these biomarkers with clinical cohorts.
We aim for improving early detection, prognosis, and immunotherapy therapy of breast cancer. Clinical collaborator: UCSD Moores Cancer Center.
We aim for development of none invasive tests for improving embryo selection during in vitro fertilization.
Predicitive models on personal response to immunotherapy by understanding single-cell behavior.